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Bertrand Liagre Selected Research

hecogenin

10/2007Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2.
2/2005Structure-function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin.
4/2003Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells.

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Bertrand Liagre Research Topics

Disease

24Neoplasms (Cancer)
11/2021 - 06/2002
10Acute Erythroblastic Leukemia (Erythroleukemia)
11/2021 - 09/2004
9Colorectal Neoplasms (Colorectal Cancer)
11/2021 - 04/2011
9Prostatic Neoplasms (Prostate Cancer)
10/2021 - 08/2012
8Rheumatoid Arthritis
06/2022 - 01/2004
6Carcinogenesis
07/2020 - 09/2004
4Inflammation (Inflammations)
03/2021 - 09/2005
4Osteosarcoma (Osteogenic Sarcoma)
02/2005 - 06/2002
3Melanoma (Melanoma, Malignant)
01/2016 - 06/2004
2Colonic Neoplasms (Colon Cancer)
12/2017 - 05/2010
2Leukemia
07/2015 - 04/2013
1Bone Diseases (Bone Disease)
03/2021
1Musculoskeletal Diseases (Musculoskeletal Disease)
03/2021
1Osteoarthritis
03/2021
1Colitis-Associated Neoplasms
07/2020
1Lung Neoplasms (Lung Cancer)
11/2019
1Autoimmune Diseases (Autoimmune Disease)
07/2019
1Adenocarcinoma
01/2015
1Carcinoma (Carcinomatosis)
10/2013
1Breast Neoplasms (Breast Cancer)
10/2009

Drug/Important Bio-Agent (IBA)

13DiosgeninIBA
11/2021 - 04/2003
9Cyclooxygenase 2 (Cyclooxygenase-2)IBA
01/2016 - 01/2004
6Biological ProductsIBA
12/2021 - 04/2003
6Phytosterols (Plant Sterols)IBA
01/2014 - 04/2003
51-phenyl-3,3-dimethyltriazene (PDT)IBA
06/2022 - 07/2017
4Photosensitizing Agents (Photosensitizers)IBA
06/2022 - 07/2017
4PorphyrinsIBA
11/2021 - 07/2017
4PolyaminesIBA
10/2021 - 01/2017
4Chalcone (Benzalacetophenone)IBA
10/2021 - 12/2016
4Ursolic AcidIBA
01/2016 - 04/2011
4Caspase 3 (Caspase-3)IBA
07/2015 - 06/2002
3RutheniumIBA
06/2022 - 11/2019
3AlkaloidsIBA
11/2019 - 02/2005
3GoldIBA
01/2019 - 01/2016
3Dinoprostone (PGE2)FDA Link
08/2017 - 01/2016
3hecogeninIBA
10/2007 - 04/2003
3sarsasapogeninIBA
10/2007 - 04/2003
3NF-kappa B (NF-kB)IBA
12/2005 - 06/2002
2LigandsIBA
11/2021 - 01/2015
2Pharmaceutical PreparationsIBA
03/2021 - 01/2016
2CyclodextrinsIBA
01/2019 - 01/2016
2EnzymesIBA
08/2017 - 04/2013
2CytokinesIBA
08/2017 - 09/2005
2ChalconesIBA
01/2017 - 10/2013
2TriterpenesIBA
01/2016 - 04/2011
2Antineoplastic Agents (Antineoplastics)IBA
01/2015 - 07/2013
2SaponinsIBA
05/2010 - 02/2005
2Arachidonic Acid (Vitamin F)IBA
05/2010 - 01/2007
1chlorinIBA
11/2021
1Bone SubstitutesIBA
03/2021
1Anti-Bacterial Agents (Antibiotics)IBA
03/2021
1Drug CarriersIBA
03/2021
1Analgesics (Analgesic Drugs)IBA
03/2021
1calcium phosphateIBA
03/2021
1Ibuprofen (Motrin)FDA LinkGeneric
03/2021
1Metformin (Glucophage)FDA LinkGeneric
07/2020
1TubulinIBA
11/2019
1Reactive Oxygen Species (Oxygen Radicals)IBA
09/2019
1Silicon Dioxide (Silica)FDA LinkGeneric
09/2019
1XylansIBA
09/2019
1CelluloseIBA
01/2019
1ArginaseIBA
04/2018
1Nitric Oxide (Nitrogen Monoxide)FDA Link
04/2018
1Messenger RNA (mRNA)IBA
08/2017
1ChemokinesIBA
08/2017
1protoporphyrin IXIBA
07/2017
1SpermineIBA
01/2017
13- hydroxy- 3',4,4',5'- tetramethoxychalconeIBA
01/2017
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
12/2016
1CurcuminIBA
02/2016
1mangostinIBA
01/2016
1Proteins (Proteins, Gene)FDA Link
01/2016
1tanshinoneIBA
01/2016
1BerberineIBA
07/2015
1CaspasesIBA
07/2015
1Carrier Proteins (Binding Protein)IBA
01/2015
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2015
1Caspase 8 (Caspase-8)IBA
01/2015
12'-hydroxy-4-methylsulfonylchalconeIBA
01/2015
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2015
1Eukaryotic Initiation Factor-4EIBA
01/2015
1Hormones (Hormone)IBA
10/2013
1Complementary DNA (cDNA)IBA
07/2013
1Casein Kinase II (Casein Kinase 2)IBA
07/2013
1Small Interfering RNA (siRNA)IBA
07/2013
1jervineIBA
04/2013
1cyclopamineIBA
04/2013
1Purinergic Receptors (Receptors, Purine)IBA
08/2012
1interferon tauIBA
07/2011
1Melanins (Melanin)IBA
07/2011
1Monophenol Monooxygenase (Tyrosinase)IBA
07/2011
1Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA
05/2010
1Volatile Oils (Essential Oils)IBA
10/2009
1citral (neral)IBA
10/2009
1p38 Mitogen-Activated Protein KinasesIBA
10/2007

Therapy/Procedure

7Therapeutics
11/2021 - 10/2010
6Photochemotherapy (Photodynamic Therapy)
06/2022 - 07/2017
5Drug Therapy (Chemotherapy)
10/2021 - 07/2011
3Chemoprevention
12/2016 - 09/2004
1Arthroplasty
10/2007